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  • Diagnostic Value of IGFBP-1 Rapid Test and Combined

    Diagnostic Value of IGFBP-1 Rapid Test and Combined IGFBP-1-AFP in ... during the labor process.1,2 The incidence of PROM is relatively high, reach-ing 10-12% of all pregnancies, making it the major cause of premature childbirth in the United States of America. The leaking of amniotic fluids is also

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  • Comparison of eight commercial PROM tests: PROM IS

    2018-9-11 · 12.5–500,000 µg/L (data not shown). On the contrary, IGFBP-1 test kit (Anhui Deep Blue Medical Technology) and IGFBP-1 Qualitative test Kit (Komdary/Tianjin Xinwan Jiezhun) exhibited a notable hook effect – a decrease in IGFBP-1 detection for high IGFBP-1 concentrations (Table 1). In this study, Actim® PROM outperformed seven other commercial

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  • RAPID TEST FOR DETECTING PREMATURE RUPTURE OF

    2017-7-21 · the IGFBP-1 bedside test can be used for the diagnosis of PROM in women with or without bleeding both at term and preterm. Kallioniemi et al, 2014 “ ” Unlike other diagnostic tests, gestational age will not affect the accuracy in detecting the presence of IGFBP-1 since the high amniotic fluid-serum ratio of IGFBP-1 is retained from the second

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  • Comment on: Guidelines for the management of

    The Alere Actim PROM test is an accurate aid in the diagnosis of suspected Premature Rupture of Membranes. It is a rapid immunoassay that specifically detects Insulin-like Growth Factor Binding Protein -1 (IGFBP-1). IGFBP-1 accumulates at high concentrations in amniotic fluid. When the membranes are ruptured, IGFBP-1 is detectable in a vaginal ...

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  • 510(k) Summary for the Medix Biochemica Actim PROM

    Medical Diagnostic Test URS-2P Glucose Protein Urinary Test Strips,Rapid Easy Use Diabetic Daily Check Urinalysis Test Kit. ... IGFBP-1 (PROM) Premature rupture of the amniotic membranes (PROM) ... High precision testing equipment Protein analysis Semi-automatic Kjeldahl Nitrogen Analyzer for sale.

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  • Fetal Fibronectin (Quick Check fFn Test) Versus Insulin ...

    2013-12-1 · Tests provided discordant results in 2 cases for both AmniSure (at dilutions 1:160 and 1:640) and actim PROM (at dilution 1:160 and 1:320) (p > 0.05). Discussion This is the first study evaluating PAMG-1 and IGFBP-1 detection in amniotic fluid in early pregnancy, with respectively AmniSure and actim PROM tests.

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  • Insulin-like Growth Factor Binding Protein-1 alpha ...

    2021-8-14 · IGFBP-1 levels were determined immunochromatographically in cervicovaginal secretions. RESULTS: Spesificity, sensitivity, positive predictivity and negative predictivity of PROM test were 100%, 96.6%, 100% and 96.9%, respectively.CONCLUSION: As a result, PROM test is a fast and safe test with high specifity and sensitivity.It is concluded that ...

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  • Clinical Policy: Testing for Rupture of Fetal Membranes

    in the diagnosis of PROM than the current diagnostic methods.7,12,14,15 Recently, a new, rapid immunoassay test (AmnioQuick® Duo+) test can detect two markers (IGFBP-1 and AFP)

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  • Testing for Rupture of Fetal Membranes

    Actim PROM test is a visually interpreted, qualitative immunochromatographic dipstick test for detection of amniotic fluid in vaginal secretions during pregnancy. Actim PROM detects IGFBP-1, which is a major protein in amniotic fluid and a marker of the amniotic fluid in a vaginal sample.

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  • RESEARCH ARTICLE Open Access Meta-analysis of studies

    2019-1-13 · Actim PROM rapid test detects insulin-like growth factor binding protein-1 (IGFBP-1) present in amniotic fluid as a marker of the presence of amniotic fluid in a cervicogenic sample -2 is synthesized in the fetal liver and detected in the amniotic fluid throughout pregnancy and the rupture of membranes would cause its displacement.

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  • Actim PROM Controls A30800ETUS-IFU LR - CooperSurgical

    2021-8-14 · Insulin-like growth factor-binding protein 1 is a member of the family of structurally homologous proteins that specifically binds and modulates the activities of IGF-1 and IGF-2. 1,2 IGFBP-1 is a 25 kilodalton protein that is produced predominantly by hepatocytes and decidualized ovarian endometrium. 3 Serum levels of IGFBP-1 exhibit considerable diurnal variation with levels highest …

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  • Headline the currently available methods.”

    2017-8-27 · lished evidence on the use of IGFBP-1 (Actim® PROM) and PAMG-1 (AmniSure®) tests and make a comparison of their performance indices (sensitivity, specificity, posi-tive predictive value [PPV] and negative predictive value [NPV]) for the diagnosis of PROM, but also to identify any variants that may influence the reported performance of both tests.

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  • NATIONAL INSTITUTE FOR HEALTH AND CARE

    2020-7-7 · 2. Actim PROM Low Positive Control (40 μg/L) 3. Actim PROM High Positive Control (250 μg/L) 4. Actim Reconstitution Solution 5. Instructions for use The Positive Controls consist of purified human insulin-like growth factor binding protein-1 (IGFBP-1) in a buffered protein solution with BSA and Thimerosal as preservative. The Negative Control ...

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  • ORIGINAL ARTICLE Comparative study of three vaginal ...

    2013-12-1 · Tests provided discordant results in 2 cases for both AmniSure (at dilutions 1:160 and 1:640) and actim PROM (at dilution 1:160 and 1:320) (p > 0.05). Discussion This is the first study evaluating PAMG-1 and IGFBP-1 detection in amniotic fluid in early pregnancy, with respectively AmniSure and actim PROM tests.

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  • AmniSure® ROM Test & PartoSure® PTL Test

    Also, ultrasound imaging of the amniotic fluid volume may also assist in diagnosis of PROM, but in individual cases such imaging may be difficult to interpret. Given the low but finite risk of complications of the dye test, the AFP and IGFBP-1 tests are often preferred as first-line tests for preterm premature rupture of membranes.

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  • Care of Women Presenting with Suspected Preterm

    2014-5-31 · Premature rupture of the membranes (PROM) is most commonly diagnosed using physical examination; however, accurate decision making in ambiguous cases is a major challenge in current obstetric practice. As this may influence a woman’s subsequent management, a number of tests designed to assist with confirming a diagnosis of PROM are commercially available.

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  • INSTRUCTIONS FOR USE

    Both these tests use a monoclonal/polyclonal antibody approach to detect two different proteins found in amniotic fluid at high concentrations. They detect Placental Protein-12 (also known as Insulin-like Growth Factor Binding Protein-1 - IGFBP-1) as well as Alpha Fetoprotein (AFP). The aim of the study is to demonstrate substantial equivalence ...

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  • Clinical Policy: Non-invasive Testing for Rupture of Fetal ...

    2020-10-7 · The Actim PROM test detects IGFBP-1, which is a major protein in amniotic fluid and a marker of the presence of amniotic fluid in a cervicovaginal sample. The test is intended for professional use to help diagnose the rupture of fetal membranes (ROM) in pregnant women at >34 weeks gestation when patients report signs, symptoms or complaints ...

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  • Diagnostic accuracy of PremaQuick in detection of

    2021-7-12 · sizes (n= 125 and n=90), as well as high false positive rates of 19-30%.1,3-4 Actim® PROM rapid test detects insulin-like growth factor binding protein-1 (IGFBP-1) present in amniotic fluid as a marker of the presence of amniotic fluid in a cervicogenic sample. IGFBP-

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  • PERFECTING GROWTH the Heat on PCR HORMONE

    The Actim ® 1ngeni System takes testing to a whole new level in the laboratory and at the point of care. Testing is easy, fast and automated — delivering a high degree of confidence and clarity to both interpretation and documentation of results. The Actim ® 1ngeni instrument offers automated analysis, display, and saving of Actim ® PROM ...

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